Enhanced Cellular Energy

WIN CoQ10 Benefits

Fatigue is typically the result of working, mental stress, jet lag or active recreation, depression, and also boredom, disease, underactive thyroid and lack of sleep. It may also have chemical causes, such as mineral or vitamin deficiencies like anemia. About 10 million doctor visits each year are attributed to fatigue. However, it remains one of the hardest terms to define and a symptom of various other conditions, often leaving it overlooked or dismissed by physicians. Around 20% of Americans claim to have fatigue intense enough to interfere with their having a normal life. Physical causes are estimated at 20-60%, and emotional causes are the other 40-80%. Fatigue is so common, that as we progress through life, we have accepted this weariness, tiredness, exhaustion, lethargy, and decrease in energy as part of the aging process.

Many fatigue sufferers attempt to boost energy with caffeine or sugar. These however are temporary fixes and often leave individuals irritable or jittery. Coenzyme Q10 provides the body with sustained, consistent energy so there is no crash, like after a sugar high, or withdrawal symptoms, like headaches.* Ninety-five percent of all the human body’s energy requirement is converted with the aid of CoQ10. WIN CoQ10 is a core component of cellular energy production and respiration, aiding the body in the production of the key power-house molecule ATP within the mitochondria. This is especially important since the natural production of CoQ10 declines with aging. WIN CoQ10 provides support to all cells of the body and is especially vital for organ tissues requiring large amounts of energy such as the heart, lungs, brain, kidneys and liver.*

Anti-Aging Antioxidant

Billions of free radicals are generated in our bodies each day, compromising our cellular components making us susceptible to diseases and even premature aging. Lacking one electron, free radicals aggressively seek out the missing electron in healthy cells, in a process called oxidation. Antioxidants protect us from these damaging effects by neutralizing the free radical’s electric charge, but unfortunately their levels decrease in our bodies due to age and the increase of environmental toxins.

Research suggests antioxidants can:

• Support the function of the aging immune system
• Decrease expression of harmful gene products and greatly reduce our risk of developing certain hereditary diseases
• Decrease age-related memory loss and mental problems
• Improve concentration and focus in people suffering from attention-deficit disorder
• Relieve symptoms of inflammatory conditions
• Decrease risk of heart disease and stroke
• Minimize the visible signs of aging skin and protect against skin cancer

WIN CoQ10’s formulation of ubiquinol is one of the most potent fat soluble antioxidants, capable of regenerating other antioxidants such as vitamin E and vitamin C.* Scientists have demonstrated that this novel form of coenzyme Q10 is vastly superior to the CoQ10 supplements that millions of Americans use today due to its higher rate of absorption and ability to remain bioavailable over a greater sustained time period.* Researchers were surprised when they found that this new form of CoQ10, available in WIN CoQ10, was 40% more effective than conventional CoQ10 in slowing the aging process.*

Heart Health

The American Heart Association estimates that nearly 71 million adults in the United States are afflicted with some form of cardiovascular disease. It’s responsible for 30% of all deaths in the United States, more than all forms of cancer combined. The energy demands of the heart are among the highest in the body, requiring energy for the ventricles of the heart to contract as they pump blood to the arteries, but needing even more energy to relax the contracted muscle. The heart must generate millions of ATP per second in every cell. Without enough ATP, heart function is compromised. By enhancing energy levels and promoting cellular and tissue health, WIN CoQ10 provides optimal support for the cardiovascular system and has the potential to provide even more benefits than conventional coQ10 because it is more readily absorbed in the digestive tract and is therefore considered more bioavailable.*

Internationally over the past 30 years, there have been at least nine placebo-controlled studies on the treatment of heart disease with CoQ10: two in Japan, two in the United States, two in Italy, two in Germany and one in Sweden. All nine of these studies have confirmed the effectiveness of CoQ10 as well as its remarkable safety. The majority of these clinical studies concerned the treatment of heart disease and were remarkably consistent in their conclusions: that treatment with CoQ10 significantly improved heart muscle function while producing no adverse effects or drug interactions.

Benefits of CoQ10 Supplementation

Congestive heart failure
A randomized double-blind trial showed that CoQ10 supplementation proved the stroke index and pulmonary artery pressure of patients with congestive heart failure. Another randomized double-blind trial found that daily CoQ10 supplementation reduced the number of congestive heart failure patients requiring hospitalization and reduced the number of episodes of pulmonary edema and cardiac asthma.

“Clinical experience with CoQ10 in heart failure is nothing short of dramatic, and it is reasonable to believe that the entire field of medicine should be re-evaluated in light of this growing knowledge. We have only scratched the surface of the clinical applications of CoQ10 and the associated fields of bioenergenetics and free radical chemistry. I have thousands of patients on CoQ10. And it’s not only their heart function that improves but many aspects of their health.”
Peter Langsjoen, M.D., FACC
Clinical Cardiologist
East Texas Medical Center and Trinity Mother Francis Health System, Tyler, TX

Cardiomyopathy
A study of patients with varying severity of cardiomyopathy revealed that deficiency of coQ10 varied with the severity of the disease and that treatment with supplemental coQ10 was effective, increasing the levels from 20% to 85%. A six-year clinical study found improved survival rates among patients receiving coQ10 supplementation in concert with a conventional medical program; in addition, 84% of the patients showed statistically significant improvement in symptoms. Furthermore, the coQ10 treatment appeared to be well tolerated.

Hypertension
There is some clinical trial evidence suggesting coQ10 has the potential to lower blood pressure. An Australian study found that coQ10 supplementation was associated with a significant decrease in systolic blood pressure and also improved glycemic control in patients with type 2 diabetes. A University of Texas study found that not only did patients treated with CoQ10 show improvements in both systolic and diastolic blood pressure, 51% were able to discontinue one to three of their anti-hypertensive drugs at an average of 4.4 months after starting CoQ10.

WIN CoQ10 and Statin Drugs

High blood cholesterol is an epidemic in the Unites States with many taking statin drugs to treat this disease. Statins effectively block the enzyme responsible for making low density lipoproteins (LDL-C) also known as “bad cholesterol”, but they also inhibit the synthesis of an intermediary precursor of Coenzyme Q10, mevalonate, since CoQ10 and cholesterol share the same metabolic pathway. In some cases, statins have reduced serum levels of coenzyme Q10 by up to 40%. Long-term ingestion of statin drugs may lead to a deficiency of CoQ10 within the body, as well as an increased risk of muscle damage and cognitive function impairment. However, the combined use of CoQ10 and statins can prevent the depletion of CoQ10 and thereby help minimize the risk of statin-induced cardiac dysfunction and other side effects. Doctors now suggest supplementation may be needed for overall health for consumers of these drugs.

Neurodegenerative Diseases

Dramatic decreases in CoQ10 have been associated with cellular dysfunction in neurodegenerative diseases such as Parkinson’s disease, Huntington’s disease and Alzheimer’s disease.

Parkinson’s Disease
Parkinson’s disease afflicts more than one million people in the United States, affecting the motor systems from a loss of dopamine-producing brain cells. Symptoms can include tremors, rigidity, bradykinesia (slowness in the execution of movement) and postural instability. This degenerative disorder of the central nervous system can also often impair the sufferer's speech.

Recently, the Parkinson’s Study Group conducted a Phase II clinical trial, assessing the effect of CoQ10 on patients following the UPDRS (Unified Parkinson’s Disease Rating Scale) which scores 1) Mentation, Behavior, and Mood, 2) Activities of Daily Living and 3) Motor sections. Eighty patients were randomly assigned to receive either placebo or CoQ10 at doses of 300, 600, or 1,200 mg per day. By 16 months, disability had slowed by 44% in the group treated with 1,200 mg per day. Also in that group, all 3 subscores of the UPDRS improved.

Huntington’s Disease
Huntington's disease's most obvious symptoms are abnormal body movements called chorea (brief, irregular muscle contractions) and a lack of coordination. It also affects a number of mental abilities and some aspects of behaviour. Physical symptoms occur in a large range of ages, with a mean occurrence in a person's late forties/early fifties. Medical evidence indicates the prescence of oxidative stress and impaired mitochondrial function in sufferers of this disease.

The Huntington’s Study Group carried out a clinical trial giving 360 patients 600 mg per day of CoQ10, 600 mg per day of remacemide, or a combination of both for 30 months. In patients treated with coQ10, there was slowing of the progression of total functional capacity scale by approximately 14%, where as no effect was seen in patients treated with remacemide. These patients also showed a slower deterioration as ssessed by HD functional assessment and HD independence scales and a trend towards beneficial impact on cognitive tasks such as reaction time, word-reading and brief tests of attention.

Alzheimer’s Disease
Alzheimer’s diseae is the most prevalent age-related neurodegenerative disorder in the world, affecting more than 13 million people. Clinical signs of Alzheimer's disease include progressive cognitive deterioration, together with declining ability to perform activities of daily living and neuropsychiatric symptoms or behavioral changes. Similar to Parkinson’s and Huntinton’s disease, there is evidence of oxidative stress and impaired energy metabolism, suggesting CoQ10 supplementation may be beneficial with clinical studies now in progress.

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